A UK survey of 575 rheumatoid arthritis sufferers highlights the importance of maintaining independence and the significant impact that early diagnosis and treatment can have. Over 94% of those surveyed claimed that their independence was compromised in some way, with over 60% saying it was compromised significantly. With earlier treatment of their disease, nearly half of the respondents felt that they would have been more independent today, making it vital that people are aware of the significance of early intervention.
Ailsa Bosworth, Chief Executive of NRAS said, "The response to this survey highlights what we already know to be true, that early treatment can make a big difference on the impact that rheumatoid arthritis can have on a person's life. Maintaining independence is so important, not only in terms of sustained quality of life and the ability to work, but also to keep personal hopes and dreams for the future alive. This Independence Day, we are encouraging people who are experiencing signs of rheumatoid arthritis, or who do not feel that their disease is currently well controlled, to seek advice from a healthcare professional as early as possible to help ensure that their independence and optimum quality of life is maintained."
In the survey, developed by Wyeth Pharmaceuticals and supported by NRAS, simple activities which are normally taken for granted are shown to be significantly affected by rheumatoid arthritis. Around 36% of those surveyed have difficulties picking up a child or grandchild, 50% have difficulties simply going to the shops and a further 68% struggle to look after their garden. In addition 60% were significantly compromised in their ability to do their job. It has been estimated that the direct and indirect cost of the condition in the UK is up to ??4.75 billion a year, largely due to lost productivity.1
Research has shown that there is much potential to improve outcomes for people with rheumatoid arthritis through earlier identification and specialist treatment2; early effective treatment for rheumatoid arthritis can maximise the chances of slowing down disease progression. This minimises joint damage and permanent disability and has a very significant impact on independence and consequently a person's overall wellbeing and quality of life.3
Rheumatoid arthritis is a chronic, progressive and disabling autoimmune condition that affects around 400,000 people in the UK with about 12,000 new cases diagnosed each year.1 It can cause stiffness, swelling and limitation in the motion and function of multiple joints. It is two to three times more common in women than men1 and can start at any age, usually between 40 and 70 years leading to irreversible joint destruction.4 Common symptoms of rheumatoid arthritis include joint pain, joint swelling, stiffness (often in the morning) and tiredness. It is a painful and distressing condition that can have a substantial impact on independence, however there is much potential to improve outcomes for people with rheumatoid arthritis through earlier identification and specialist treatment.2
References
1. NICE Clinical Guideline 79. Rheumatoid Arthritis: The Management of Rheumatoid Arthritis in Adults. February 2009.
2. The King's Fund Report for the Rheumatology Futures Group. Perceptions of patients and professionals on rheumatoid arthritis care. Available Online: here. Last Accessed June 2009.
3. Sokka R. Work Disability in Early Rheumatoid Arthritis. Clinical and Experimental Rheumatology 2003:21 (suppl 31):S71-S74.
4. Lee DM, Weinblatt ME. Rheumatoid Arthritis. Lancet 2001; 358: 903-911.
Source
Wyeth Pharmaceuticals
воскресенье, 2 октября 2011 г.
четверг, 29 сентября 2011 г.
Current And Emerging Drugs Have No Advantage Over Enbrel In Inhibiting/Slowing The Progression Of Rheumatoid Arthritis
Decision Resources, one
of the world's leading research and advisory firms focusing on
pharmaceutical and healthcare issues, finds that a drug's effect on
inhibiting/slowing the progression of structural damage and reducing the
signs and symptoms of rheumatoid arthritis during the first year of
treatment are the attributes that most influence surveyed rheumatologists'
prescribing decisions in the treatment of the disease. Clinical data and
expert opinion shows that current and emerging therapies have no advantage
in these attributes over the market sales leader, Amgen/Wyeth/Takeda's
Enbrel.
The new report entitled Rheumatoid Arthritis: Competitive, Crowded
Market Sets the Bar High for Novel Agents finds that, through 2016, there
are no therapies in development that will displace Enbrel as the clinical
gold standard treatment for rheumatoid arthritis. While some therapies in
development for the disease hold promise, most have efficacy, safety and
tolerability, and/or delivery features that are inferior when compared with
Enbrel.
The overall efficacy of emerging therapies such as
Centocor/Schering-Plough/Mitsubishi Tanabe/Janssen's golimumab and Biogen
Idec/Genentech/Roche's ocrelizumab is comparable to that of Enbrel, while
the overall safety and tolerability for emerging therapies that include
ocrelizumab and UCB's Cimzia are also comparable to that of Enbrel.
However, the currently available clinical data for golimumab, ocrelizumab
and Cimzia is not as robust or extensive as those available for Enbrel.
"While emerging therapies such as golimumab and Cimzia offer superior
delivery to that of Enbrel due to improved dosing frequencies, these
agents' overall efficacy, safety and tolerability, respectively, are
inferior to those of Enbrel-and efficacy, safety and tolerability are
weighted more heavily by surveyed rheumatologists as key drivers of
prescribing decisions," said Cindy Mundy, Ph.D., director at Decision
Resources. "As a result, the improvements in dosing frequency that
golimumab and Cimzia offer over Enbrel are not sufficient to propel either
agent to the position of future gold standard."
About the Report
Rheumatoid Arthritis: Competitive, Crowded Market Sets the Bar High for
Novel Agents is a DecisionBase 2008 report from Decision Resources.
DecisionBase 2008 combines market forecasts with clinical and commercial
end points to assess market share projections in 35 indications. These
outputs are driven by quantitative and qualitative primary research.
DecisionBase 2008 provides detailed market share, patient share, and
price-per-day projections for emerging drugs in development. The market
share projections are based on prescriber surveys that compare physicians'
expectations of a potential target product profile with an emerging product
profile of the leading drugs in development.
The report can be purchased by contacting Decision Resources. Members
of the media may request an interview with an analyst.
About Decision Resources
Decision Resources, Inc. (decisionresources) is a world
leader in market research publications, advisory services, and consulting
designed to help clients shape strategy, allocate resources, and master
their chosen markets. Decision Resources is a Decision Resources, Inc.
company.
All company, brand, or product names contained in this document may be
trademarks or registered trademarks of their respective holders.
Decision Resources, Inc.
decisionresources
View drug information on Cimzia; Enbrel.
of the world's leading research and advisory firms focusing on
pharmaceutical and healthcare issues, finds that a drug's effect on
inhibiting/slowing the progression of structural damage and reducing the
signs and symptoms of rheumatoid arthritis during the first year of
treatment are the attributes that most influence surveyed rheumatologists'
prescribing decisions in the treatment of the disease. Clinical data and
expert opinion shows that current and emerging therapies have no advantage
in these attributes over the market sales leader, Amgen/Wyeth/Takeda's
Enbrel.
The new report entitled Rheumatoid Arthritis: Competitive, Crowded
Market Sets the Bar High for Novel Agents finds that, through 2016, there
are no therapies in development that will displace Enbrel as the clinical
gold standard treatment for rheumatoid arthritis. While some therapies in
development for the disease hold promise, most have efficacy, safety and
tolerability, and/or delivery features that are inferior when compared with
Enbrel.
The overall efficacy of emerging therapies such as
Centocor/Schering-Plough/Mitsubishi Tanabe/Janssen's golimumab and Biogen
Idec/Genentech/Roche's ocrelizumab is comparable to that of Enbrel, while
the overall safety and tolerability for emerging therapies that include
ocrelizumab and UCB's Cimzia are also comparable to that of Enbrel.
However, the currently available clinical data for golimumab, ocrelizumab
and Cimzia is not as robust or extensive as those available for Enbrel.
"While emerging therapies such as golimumab and Cimzia offer superior
delivery to that of Enbrel due to improved dosing frequencies, these
agents' overall efficacy, safety and tolerability, respectively, are
inferior to those of Enbrel-and efficacy, safety and tolerability are
weighted more heavily by surveyed rheumatologists as key drivers of
prescribing decisions," said Cindy Mundy, Ph.D., director at Decision
Resources. "As a result, the improvements in dosing frequency that
golimumab and Cimzia offer over Enbrel are not sufficient to propel either
agent to the position of future gold standard."
About the Report
Rheumatoid Arthritis: Competitive, Crowded Market Sets the Bar High for
Novel Agents is a DecisionBase 2008 report from Decision Resources.
DecisionBase 2008 combines market forecasts with clinical and commercial
end points to assess market share projections in 35 indications. These
outputs are driven by quantitative and qualitative primary research.
DecisionBase 2008 provides detailed market share, patient share, and
price-per-day projections for emerging drugs in development. The market
share projections are based on prescriber surveys that compare physicians'
expectations of a potential target product profile with an emerging product
profile of the leading drugs in development.
The report can be purchased by contacting Decision Resources. Members
of the media may request an interview with an analyst.
About Decision Resources
Decision Resources, Inc. (decisionresources) is a world
leader in market research publications, advisory services, and consulting
designed to help clients shape strategy, allocate resources, and master
their chosen markets. Decision Resources is a Decision Resources, Inc.
company.
All company, brand, or product names contained in this document may be
trademarks or registered trademarks of their respective holders.
Decision Resources, Inc.
decisionresources
View drug information on Cimzia; Enbrel.
понедельник, 26 сентября 2011 г.
AMA Welcomes New Body To Combat Rheumatic Heart Disease, Australia
AMA Vice President and Chair of the AMA Taskforce on Indigenous Health, Dr Steve Hambleton, said today that RHDAustralia is an important first step towards eradicating rheumatic heart disease among Indigenous people.
The Government has provided RHDAustralia with $2.5 million over four years to combat rheumatic heart disease, which is a major killer of Aboriginal and Torres Strait Islander people.
"For several years, the AMA has been calling for a coordinated national effort to eradicate rheumatic heart disease among Indigenous people," Dr Hambleton said.
"Acute rheumatic fever and rheumatic heart disease can be prevented if the right screening, management and notification processes - and follow up - are put in place.
"Now that this initiative has commenced with RHDAustralia, we would like the Government to continue to build on the momentum by implementing the $11.2 million Rheumatic Fever Strategy that was promised prior to the 2007 election.
"The AMA believes it is essential that RHDAustralia keeps all the relevant stakeholders involved and informed, especially when it comes to the development of a national register and refinement of best practice guidelines.
"Stakeholders include Indigenous communities, health services, individual doctors, and their representative organisations," Dr Hambleton said.
Source
Australian Medical Association
The Government has provided RHDAustralia with $2.5 million over four years to combat rheumatic heart disease, which is a major killer of Aboriginal and Torres Strait Islander people.
"For several years, the AMA has been calling for a coordinated national effort to eradicate rheumatic heart disease among Indigenous people," Dr Hambleton said.
"Acute rheumatic fever and rheumatic heart disease can be prevented if the right screening, management and notification processes - and follow up - are put in place.
"Now that this initiative has commenced with RHDAustralia, we would like the Government to continue to build on the momentum by implementing the $11.2 million Rheumatic Fever Strategy that was promised prior to the 2007 election.
"The AMA believes it is essential that RHDAustralia keeps all the relevant stakeholders involved and informed, especially when it comes to the development of a national register and refinement of best practice guidelines.
"Stakeholders include Indigenous communities, health services, individual doctors, and their representative organisations," Dr Hambleton said.
Source
Australian Medical Association
пятница, 23 сентября 2011 г.
Rheumatoid Arthritis Impacts Millions Of Americans But Remains Severely Underfunded
Rheumatoid arthritis (RA) affects 2.1
million Americans and despite many advances in the understanding of the
disease, funds for research remain limited and both the cause and a cure
are still unknown. The American College of Rheumatology Research and
Education Foundation (ACR REF) is working to accelerate RA research and
expand financial support of this disease by launching the Within Our Reach:
Finding a Cure for Rheumatoid Arthritis campaign. The new program is
designed to raise unprecedented funds to search for a cure.
RA is the most common form of inflammatory arthritis and costs society
more than $80 billion each year. The disease affects more than one in every
200 Americans. However, research funding for RA averages as little as
$25.90 per patient and remains significantly low compared to other chronic
diseases that affect far fewer people like lupus, diabetes and multiple
sclerosis, which average $330.00 per patient. Despite the lack of funding,
research has led to more effective and aggressive, treatments as well as a
better understanding of how to manage the disease.
"Therapy for patients with RA has improved dramatically, and we also
have learned that early diagnosis is essential," said Dr. James R. O'Dell,
president of the REF. "While there is no cure, patients who receive
treatment early feel better and are more likely to lead an active life.
Painful symptoms including inflammation and joint damage can be minimized
with early treatment and further research will continue to better patients'
lives and get us closer to a cure."
Rheumatoid Arthritis Symptoms and Diagnosis
RA is a chronic, autoimmune disease that develops because certain cells
of the immune system malfunction and attack healthy joints. It is far more
common in women than many expect. Approximately 1 to 3 percent of women may
develop RA in their lifetime, which is three times more common in women as
in men. While symptoms most often begin between the fourth and sixth
decades of life, RA can develop at any age.
Pain, stiffness, swelling, and limitation in the motion and function of
multiple joints are the most common symptoms. Though joints are the
principal body parts affected by RA, inflammation can develop in other
organs as well. Additional warning signs also include:
-- Loss of energy
-- Low-grade fevers
-- Loss of appetite
-- Dry eyes and mouth from an associated condition known as Sjogren's
syndrome
-- Firm lumps called rheumatoid nodules beneath the skin in areas such as
the elbow and hands
RA can be difficult to diagnose because it may begin gradually and many
diseases behave in a manner similar to RA. Patients suspected of having RA
should be evaluated by a rheumatologist, a physician with the necessary
skill and experience to reach a precise diagnosis and develop the most
appropriate treatment plan.
Patients can visit rheumatology/directory to find a
rheumatologist in their area.
About Within Our Reach: Finding a Cure for Rheumatoid Arthritis
Campaign
Within Our Reach is a national, multi-year fundraising campaign with a
goal to raise $30 million towards accelerating innovative research focused
specifically on rheumatoid arthritis. It is the largest private fundraising
campaign in the REF's history, which will tap a diverse donor base,
supporting innovative research to learn more about the causes of RA and,
ultimately, to find a cure. Since November, the campaign has received
tremendous support from the pharmaceutical industry, biotech companies,
physicians and patients.
"Today, more funding needs to be directed towards the kind of RA
research that goes beyond treatment only - the kind of RA research that
seeks to find a cure through better understanding of the causes of and
preventions for this devastating disease," added Dr. O'Dell. "With the
guidance of ACR Research and Education Foundation, Within Our Reach will
allow more of this type of research to be conducted and together we can
work to find a cure."
To learn more about rheumatoid arthritis and Within Our Reach, please
visit WithinOurReach.
About the ACR Research and Education Foundation
The ACR Research and Education Foundation was established in 1985 as a
501(c)(3) with a mission to improve patients' lives through support of
research and training that advances the prevention, treatment and cure of
rheumatic diseases. Since its founding, the REF has promoted and advanced
the field of rheumatology by funding research, training and education
opportunities for clinicians, students, health professionals, researchers
and academic institutions. On average, 90 cents of every dollar donated to
the REF is used to fund its extensive award and grant program.
American College of Rheumatology Research and Education Foundation
WithinOurReach
million Americans and despite many advances in the understanding of the
disease, funds for research remain limited and both the cause and a cure
are still unknown. The American College of Rheumatology Research and
Education Foundation (ACR REF) is working to accelerate RA research and
expand financial support of this disease by launching the Within Our Reach:
Finding a Cure for Rheumatoid Arthritis campaign. The new program is
designed to raise unprecedented funds to search for a cure.
RA is the most common form of inflammatory arthritis and costs society
more than $80 billion each year. The disease affects more than one in every
200 Americans. However, research funding for RA averages as little as
$25.90 per patient and remains significantly low compared to other chronic
diseases that affect far fewer people like lupus, diabetes and multiple
sclerosis, which average $330.00 per patient. Despite the lack of funding,
research has led to more effective and aggressive, treatments as well as a
better understanding of how to manage the disease.
"Therapy for patients with RA has improved dramatically, and we also
have learned that early diagnosis is essential," said Dr. James R. O'Dell,
president of the REF. "While there is no cure, patients who receive
treatment early feel better and are more likely to lead an active life.
Painful symptoms including inflammation and joint damage can be minimized
with early treatment and further research will continue to better patients'
lives and get us closer to a cure."
Rheumatoid Arthritis Symptoms and Diagnosis
RA is a chronic, autoimmune disease that develops because certain cells
of the immune system malfunction and attack healthy joints. It is far more
common in women than many expect. Approximately 1 to 3 percent of women may
develop RA in their lifetime, which is three times more common in women as
in men. While symptoms most often begin between the fourth and sixth
decades of life, RA can develop at any age.
Pain, stiffness, swelling, and limitation in the motion and function of
multiple joints are the most common symptoms. Though joints are the
principal body parts affected by RA, inflammation can develop in other
organs as well. Additional warning signs also include:
-- Loss of energy
-- Low-grade fevers
-- Loss of appetite
-- Dry eyes and mouth from an associated condition known as Sjogren's
syndrome
-- Firm lumps called rheumatoid nodules beneath the skin in areas such as
the elbow and hands
RA can be difficult to diagnose because it may begin gradually and many
diseases behave in a manner similar to RA. Patients suspected of having RA
should be evaluated by a rheumatologist, a physician with the necessary
skill and experience to reach a precise diagnosis and develop the most
appropriate treatment plan.
Patients can visit rheumatology/directory to find a
rheumatologist in their area.
About Within Our Reach: Finding a Cure for Rheumatoid Arthritis
Campaign
Within Our Reach is a national, multi-year fundraising campaign with a
goal to raise $30 million towards accelerating innovative research focused
specifically on rheumatoid arthritis. It is the largest private fundraising
campaign in the REF's history, which will tap a diverse donor base,
supporting innovative research to learn more about the causes of RA and,
ultimately, to find a cure. Since November, the campaign has received
tremendous support from the pharmaceutical industry, biotech companies,
physicians and patients.
"Today, more funding needs to be directed towards the kind of RA
research that goes beyond treatment only - the kind of RA research that
seeks to find a cure through better understanding of the causes of and
preventions for this devastating disease," added Dr. O'Dell. "With the
guidance of ACR Research and Education Foundation, Within Our Reach will
allow more of this type of research to be conducted and together we can
work to find a cure."
To learn more about rheumatoid arthritis and Within Our Reach, please
visit WithinOurReach.
About the ACR Research and Education Foundation
The ACR Research and Education Foundation was established in 1985 as a
501(c)(3) with a mission to improve patients' lives through support of
research and training that advances the prevention, treatment and cure of
rheumatic diseases. Since its founding, the REF has promoted and advanced
the field of rheumatology by funding research, training and education
opportunities for clinicians, students, health professionals, researchers
and academic institutions. On average, 90 cents of every dollar donated to
the REF is used to fund its extensive award and grant program.
American College of Rheumatology Research and Education Foundation
WithinOurReach
вторник, 20 сентября 2011 г.
MabThera(R) Virtual Clinic Gives Rheumatologists Real-Life Patient Insight
The MabThera Virtual Clinic - an exciting web-based resource - is a new initiative that provides physicians with key insights into the use of MabThera (rituximab), the first and only selective B cell therapy for the treatment of rheumatoid arthritis (RA).
Using anonymised real-life cases of RA patients from around the world, the Virtual Clinic details the experiences of practicing rheumatologists prescribing MabThera. It features an overview of patients' medical history and their treatment strategies. The cases demonstrate the clinical aspects of using MabThera, illustrating the efficacy, safety and duration of response with each course of treatment, helping physicians to identify those patients that would benefit the most from treatment.
The Virtual Clinic is an interactive resource tool which allows physicians to access cases according to specific clinical dilemmas and to view how MabThera is being used in clinical practice. It gives physicians an opportunity to share and learn from experience made by their colleagues.
The MabThera Virtual Clinic forms part of Roche's commitment to improving the lives of people living with RA, one of the most common forms of autoimmune disease which affects over 21 million people worldwide. [1]
The MabThera Virtual Clinic is available at MabThera-RA.
References
[1] United Nations World Population Database, 2004 revision. use.un/unpp
Using anonymised real-life cases of RA patients from around the world, the Virtual Clinic details the experiences of practicing rheumatologists prescribing MabThera. It features an overview of patients' medical history and their treatment strategies. The cases demonstrate the clinical aspects of using MabThera, illustrating the efficacy, safety and duration of response with each course of treatment, helping physicians to identify those patients that would benefit the most from treatment.
The Virtual Clinic is an interactive resource tool which allows physicians to access cases according to specific clinical dilemmas and to view how MabThera is being used in clinical practice. It gives physicians an opportunity to share and learn from experience made by their colleagues.
The MabThera Virtual Clinic forms part of Roche's commitment to improving the lives of people living with RA, one of the most common forms of autoimmune disease which affects over 21 million people worldwide. [1]
The MabThera Virtual Clinic is available at MabThera-RA.
References
[1] United Nations World Population Database, 2004 revision. use.un/unpp
суббота, 17 сентября 2011 г.
Although Women Live Longer, They Do Not Live Better, Largely Because Of Obesity And Arthritis
Obesity and arthritis that take root during early and middle age significantly contribute to women's decreased quality of life during their senior years, according to researchers at Duke University Medical Center.
In a study that included 5,888 people over 65, women suffered up to two and a half times more disabilities than men of the same age.
Higher rates of obesity and arthritis among these women explained up to 48 percent of the gender gap in disability - above all other common chronic health conditions.
"While women tend to live longer than men, this study shows that they are at greater risk of living with disability and much of the excess disability is attributable to higher rates of obesity and arthritis," said Heather Whitson, M.D., assistant professor of medicine and lead investigator of the study presented at the Annual Scientific Meeting of the American Geriatrics Society. "This is important because it suggests that women's tendency to pack on extra pounds in their child-bearing and peri-menopausal years translates into loss of independence in their old age."
Researchers said the study is the first to isolate the impact of specific chronic health conditions on the difference in disability rates between older men and women. While many people are studying how chronic conditions affect mortality, the investigators were surprised to see the extent to which these conditions explained the gender difference in disability.
"The reason for this discrepancy in disability has not been well understood but we found that chronic health conditions that women experience in greater numbers than men may explain part of that gap," said Harvey Jay Cohen, M.D., the study's senior author, chair of the Department of Medicine and director of Duke's Center for the Study of Aging and Human Development.
"Women have a natural tendency to gain more weight than men over the lifespan, but may be more motivated to maintain a healthy weight if they realize that those extra pounds make it more likely that they will be disabled in later years - potentially becoming a burden to their children or requiring a nursing home," Whitson said.
The current study is an analysis of the Cardiovascular Health Study which asked participants about their ability to conduct common activities of daily living, such as grooming, eating, getting dressed, managing money and upper and lower body movement, including reaching, grasping, walking and climbing stairs.
The Duke team said the study also draws attention to two concerning health trends that could worsen the average quality of life for women in the future. First, as the rate of obesity continues to rise, the rates of disability in older adults are expected to increase. To the extent that women are more likely than men to develop obesity, the obesity epidemic will have its greatest impact on older women's quality of life.
Second, the investigators note that women are gaining equality with men on cardiovascular disease, stroke and emphysema, which had previously been less common among women. Rates of cardiovascular disease are not improving as quickly among women as they are among men and smoking-related disease is becoming more common in women. If the occurrence of these conditions becomes more comparable between men and women, the result would be an even wider gap in disability rates.
"The findings of our study are more troubling when you consider the increasing rates of obesity among women and the higher rates of other conditions that are currently over-represented among men," Cohen said. "We need to help women make better decisions earlier in life."
In addition to obesity and arthritis, the study found the women were more likely than men to experience fractures, vision problems and bronchitis. Men were more likely to have emphysema, coronary heart disease, congestive heart failure, stroke, diabetes and hearing problems.
Researchers say that the next step is to determine whether older women who have been disabled by obesity or arthritis regain function if they undergo treatment to help them achieve a healthy weight or to control their arthritis pain. If not, then it becomes even more important to focus efforts on preventing obesity and arthritis in younger populations.
Study co-authors include Drs. Lawrence L. Landerman, Anne B Newman, Linda P. Fried and Carl F. Pieper.
The research was supported by National Institutes of Health, University of Pittsburgh Claude D. Pepper Older Americans Independence Center, John A. Hartford Center for Excellence, Duke Claude D. Pepper Older American Independence Center, a John A. Hartford Foundation Geriatrics Outcomes Research Award and Paul B. Beeson Career Development Award.
Source:
Melissa Schwarting
Duke University Medical Center
In a study that included 5,888 people over 65, women suffered up to two and a half times more disabilities than men of the same age.
Higher rates of obesity and arthritis among these women explained up to 48 percent of the gender gap in disability - above all other common chronic health conditions.
"While women tend to live longer than men, this study shows that they are at greater risk of living with disability and much of the excess disability is attributable to higher rates of obesity and arthritis," said Heather Whitson, M.D., assistant professor of medicine and lead investigator of the study presented at the Annual Scientific Meeting of the American Geriatrics Society. "This is important because it suggests that women's tendency to pack on extra pounds in their child-bearing and peri-menopausal years translates into loss of independence in their old age."
Researchers said the study is the first to isolate the impact of specific chronic health conditions on the difference in disability rates between older men and women. While many people are studying how chronic conditions affect mortality, the investigators were surprised to see the extent to which these conditions explained the gender difference in disability.
"The reason for this discrepancy in disability has not been well understood but we found that chronic health conditions that women experience in greater numbers than men may explain part of that gap," said Harvey Jay Cohen, M.D., the study's senior author, chair of the Department of Medicine and director of Duke's Center for the Study of Aging and Human Development.
"Women have a natural tendency to gain more weight than men over the lifespan, but may be more motivated to maintain a healthy weight if they realize that those extra pounds make it more likely that they will be disabled in later years - potentially becoming a burden to their children or requiring a nursing home," Whitson said.
The current study is an analysis of the Cardiovascular Health Study which asked participants about their ability to conduct common activities of daily living, such as grooming, eating, getting dressed, managing money and upper and lower body movement, including reaching, grasping, walking and climbing stairs.
The Duke team said the study also draws attention to two concerning health trends that could worsen the average quality of life for women in the future. First, as the rate of obesity continues to rise, the rates of disability in older adults are expected to increase. To the extent that women are more likely than men to develop obesity, the obesity epidemic will have its greatest impact on older women's quality of life.
Second, the investigators note that women are gaining equality with men on cardiovascular disease, stroke and emphysema, which had previously been less common among women. Rates of cardiovascular disease are not improving as quickly among women as they are among men and smoking-related disease is becoming more common in women. If the occurrence of these conditions becomes more comparable between men and women, the result would be an even wider gap in disability rates.
"The findings of our study are more troubling when you consider the increasing rates of obesity among women and the higher rates of other conditions that are currently over-represented among men," Cohen said. "We need to help women make better decisions earlier in life."
In addition to obesity and arthritis, the study found the women were more likely than men to experience fractures, vision problems and bronchitis. Men were more likely to have emphysema, coronary heart disease, congestive heart failure, stroke, diabetes and hearing problems.
Researchers say that the next step is to determine whether older women who have been disabled by obesity or arthritis regain function if they undergo treatment to help them achieve a healthy weight or to control their arthritis pain. If not, then it becomes even more important to focus efforts on preventing obesity and arthritis in younger populations.
Study co-authors include Drs. Lawrence L. Landerman, Anne B Newman, Linda P. Fried and Carl F. Pieper.
The research was supported by National Institutes of Health, University of Pittsburgh Claude D. Pepper Older Americans Independence Center, John A. Hartford Center for Excellence, Duke Claude D. Pepper Older American Independence Center, a John A. Hartford Foundation Geriatrics Outcomes Research Award and Paul B. Beeson Career Development Award.
Source:
Melissa Schwarting
Duke University Medical Center
среда, 14 сентября 2011 г.
Osteoarthritis Increases Aggregate Health Care Expenditures By $186 Billion Annually
Osteoarthritis (OA), a highly prevalent disease, raised aggregate annual medical care expenditures in the U.S. by $185.5 billion according to researchers from Stony Brook University. Insurers footed $149.4 billion of the total medical spend and out-of-pocket (OOP) expenditures were $36.1 billion (2007 dollars). Results of the cost analysis study are published in the December issue of Arthritis & Rheumatism, a journal of the American College of Rheumatology.
The Centers for Disease Control and Prevention (CDC) estimate 27 million Americans suffer from OA with more women than men affected by the disease. Forecasts indicate that by the year 2030, 25% of the adult U.S. population, or nearly 67 million people, will have physician-diagnosed arthritis. OA is a major debilitating disease causing gradual loss of cartilage, primarily affecting the knees, hips, hands, feet, and spine.
John Rizzo, Ph.D., and colleagues used data from the 1996-2005 Medical Expenditure Panel Survey (MEPS) to determine the overall annual expected medical care expenditures for OA in the U.S. The sample included 84,647 women and 70,590 men aged 18 years and older who had health insurance. Expenditures for physician, hospital, and outpatient services, as well expenditures for drugs, diagnostic testing, and related medical services were included. Healthcare expenses were expressed in 2007 dollars using the Medical Care Component of the Consumer Price Index.
Researchers, using multivariable regression models, determined annual insurer healthcare expenditures were $4,833 for women and $4,036 for men. Out-of-pocket expenses were also higher in women than men, at $1,379 and $694, respectively. "Understanding the economic costs of OA is important for payors, providers, patients, and other stakeholders," said. Rizzo. "Our study clearly reflects the significant impact of OA on U.S. healthcare spending."
Further analysis provided aggregate data based upon arthritis prevalence rates reported in a study by Helmick et al., and also published in Arthritis and Rheumatism (2008). The current study determined that OA increased insurer costs by $149.4 billion and OOP expenditures by 36.1 billion annually, for an aggregate increase of $185.5 billion per year. According to the authors women accounted for more of the expenditures ($118 billion) than men ($67.5 billion), reflecting the higher occurrence of the disease among women.
In recent years the prevalence of OA has risen rapidly and this trend is expected to continue. Increased awareness and better screening to identify patients with OA may help to delay disease progression and its debilitating effects which could mitigate costs to insurers and patients. "Our results suggest that patients with OA may benefit from greater efforts to promote exercise, proper medication use, and appropriate surgical treatments for the disease," concluded Dr. Rizzo.
Article: "Insurer and Out-of-Pocket Costs of Osteoarthritis in the US." Harry Kotlarz, Candace L. Gunnarsson, Hai Fang, and John A. Rizzo. Arthritis & Rheumatism; Published Online: November 30, 2009 (DOI 10.1002/art.24984); Print Issue Date: December 2009.
Source: Dawn Peters
Wiley-Blackwell
The Centers for Disease Control and Prevention (CDC) estimate 27 million Americans suffer from OA with more women than men affected by the disease. Forecasts indicate that by the year 2030, 25% of the adult U.S. population, or nearly 67 million people, will have physician-diagnosed arthritis. OA is a major debilitating disease causing gradual loss of cartilage, primarily affecting the knees, hips, hands, feet, and spine.
John Rizzo, Ph.D., and colleagues used data from the 1996-2005 Medical Expenditure Panel Survey (MEPS) to determine the overall annual expected medical care expenditures for OA in the U.S. The sample included 84,647 women and 70,590 men aged 18 years and older who had health insurance. Expenditures for physician, hospital, and outpatient services, as well expenditures for drugs, diagnostic testing, and related medical services were included. Healthcare expenses were expressed in 2007 dollars using the Medical Care Component of the Consumer Price Index.
Researchers, using multivariable regression models, determined annual insurer healthcare expenditures were $4,833 for women and $4,036 for men. Out-of-pocket expenses were also higher in women than men, at $1,379 and $694, respectively. "Understanding the economic costs of OA is important for payors, providers, patients, and other stakeholders," said. Rizzo. "Our study clearly reflects the significant impact of OA on U.S. healthcare spending."
Further analysis provided aggregate data based upon arthritis prevalence rates reported in a study by Helmick et al., and also published in Arthritis and Rheumatism (2008). The current study determined that OA increased insurer costs by $149.4 billion and OOP expenditures by 36.1 billion annually, for an aggregate increase of $185.5 billion per year. According to the authors women accounted for more of the expenditures ($118 billion) than men ($67.5 billion), reflecting the higher occurrence of the disease among women.
In recent years the prevalence of OA has risen rapidly and this trend is expected to continue. Increased awareness and better screening to identify patients with OA may help to delay disease progression and its debilitating effects which could mitigate costs to insurers and patients. "Our results suggest that patients with OA may benefit from greater efforts to promote exercise, proper medication use, and appropriate surgical treatments for the disease," concluded Dr. Rizzo.
Article: "Insurer and Out-of-Pocket Costs of Osteoarthritis in the US." Harry Kotlarz, Candace L. Gunnarsson, Hai Fang, and John A. Rizzo. Arthritis & Rheumatism; Published Online: November 30, 2009 (DOI 10.1002/art.24984); Print Issue Date: December 2009.
Source: Dawn Peters
Wiley-Blackwell
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